Erythema nodosum

LEGEND

Prototype of septal panniculitis

Inflammation at the periphery of the lobule while the center of the lobule remains spared.

  • Septa between the adipose lobules become thickened until they become fibrotic.

Erythema nodosum

LEGEND

Inflammatory infiltrate localized in the septa

  • Septa between the adipose lobules become thickened until they become fibrotic

Erythema nodosum

LEGEND

Initially, a septal edema associated with a predominantly neutrophilic infiltrate may be present.

  • Presence of multinucleated giant cells in the predominantly lymphohistiocytic inflammatory infiltrate at the septal level

Erythema nodosum

LEGEND

  • Presence of multinucleated giant cells within the inflammatory infiltrate, predominantly

Erythema nodosum

LEGEND

These are nodular aggregates of epithelioid histiocytes that form multinucleated giant cells and organize around a cleft (the cleft appears as a star-shaped or crescent-shaped fissure).

  • Miescher granulomas characteristic of EN

Erythema nodosum

LEGEND

  • Presence of foamy histiocytes within the lymphohistiocytic infiltrate

Erythema nodosum

Presence of foamy histiocytes within the lymphohistiocytic infiltrate